All Skills

Expert .NET Core specialist mastering .NET 10 with modern C# features. Specializes in cross-platform development, minimal APIs, cloud-native applications, and microservices with focus on building high-performance, scalable solutions.

Distributed systems architect designing scalable microservice ecosystems. Masters service boundaries, communication patterns, and operational excellence in cloud-native environments.

Managing Linear issues, projects, and teams. Use when working with Linear tasks, creating issues, updating status, querying projects, or managing team workflows.

Turn ideas into fully formed designs and specs through natural collaborative dialogue. Use when planning new features, designing architecture, or making significant changes to the codebase.

Turn ideas into fully formed designs and specs through natural collaborative dialogue. Use when planning new features, designing architecture, or making significant changes to the codebase.

Dynamic multi-repo and monorepo awareness for Claude Code. Analyze workspace topology, track API contracts, and maintain cross-repo context.

Shopify app development - Remix, Admin API, checkout extensions

Core Supabase CLI, migrations, RLS, Edge Functions

GWAS Fine-Mapping & Causal Variant Prioritization

Trace drug mechanism of action — primary target → downstream signaling → pathway perturbation → tissue/organ effect → clinical outcome. Uses DrugBank, ChEMBL, KEGG, Reactome, STRING. Use for understanding how a drug works, identifying off-target effects, mechanism-based combination therapy design, and writing mechanism sections of reports.

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GWAS SNP Interpretation Skill

Structural biology plus proteomics integration for drug target validation. Combines PDB experimental structures, AlphaFold predictions, GPCRdb, SAbDab antibody structures, ProteinsPlus binding-site prediction, BindingDB ligand-affinity data, BMRB NMR data, CATH/InterPro fold classification, intrinsic-disorder prediction (MobiDB/DisProt/IUPred3), membrane-protein topology (OPM/TopDB/PDBTM/ChannelsDB), enzyme catalytic-site data (M-CSA), PDBe ligand/compound chemistry, and MD simulation trajectory metadata (MDDB). Use for druggability assessment, binding-site characterization, ligand-pocket analysis, structural-confidence scoring (resolution, pLDDT), antibody-target interface analysis, disordered-region assessment, membrane-protein topology, catalytic-mechanism lookup, and finding published MD simulations for a target.

Comprehensive drug-target intelligence — tissue expression (GTEx, HPA), pathways, protein interactions (STRING), variant landscape (ClinVar, gnomAD), druggability (DGIdb, ChEMBL approved drugs). 9 parallel research paths with citations. Use for full target profile reports, target characterization for drug discovery, and 'tell me about target X' queries.

Build autonomous AI agents with Claude Agent SDK. Structured outputs guarantee JSON schema validation, with plugins system and hooks for event-driven workflows. Prevents 14 documented errors. Use when: building coding agents, SRE systems, security auditors, or troubleshooting CLI not found, structured output validation, session forking errors, MCP config issues, subagent cleanup.

Build content-heavy sites with Git-backed TinaCMS. Provides visual editing for blogs, documentation, and marketing sites. Supports Next.js, Vite+React, and Astro with TinaCloud or Node.js self-hosting. Prevents 10 documented errors. Use when setting up CMS with non-technical editors or troubleshooting ESbuild compilation, module resolution, package manager compatibility, edge runtime limitations, or media upload timeouts.

Set up Sveltia CMS - lightweight Git-backed CMS successor to Decap/Netlify CMS (300KB bundle, 270+ fixes). Framework-agnostic for Hugo, Jekyll, 11ty, Astro. Prevents 10 documented errors. Use when adding CMS to static sites, migrating from Decap CMS, or fixing OAuth, YAML parse, datetime timezone, GDPR font loading, or CORS/COOP errors.

GitHub Spec-Kit integration for constitution-based spec-driven development. 7-phase workflow. Triggers: "spec-kit", "speckit", "constitution", "specify", ".specify/", "规格驱动开发", "需求规格".

Expert React software architect specializing in frontend architecture, component design patterns, state management strategies, and performance optimization. Reviews React codebases for architectural integrity, proper component composition, and best practices across React 19, Next.js, Remix, and modern frontend frameworks. Use PROACTIVELY for React architectural decisions, frontend design patterns, and complex UI architecture reviews.

Expert AWS Solution Architect specializing in scalable cloud architectures, Well-Architected Framework, and enterprise-grade AWS solutions. Masters multi-region deployments, high availability patterns, cost optimization, and security best practices. Use PROACTIVELY for AWS architecture design, cloud migration strategies, or Well-Architected reviews.

Expert TypeScript software architect specializing in Clean Architecture, Domain-Driven Design (DDD), Node.js patterns, and modern TypeScript frameworks. Reviews TypeScript codebases for architectural integrity, proper separation of concerns, and best practices across Express, Fastify, NestJS, and other frameworks. Use PROACTIVELY for TypeScript architectural decisions, DDD modeling, and modern JavaScript/TypeScript patterns.

Expert NestJS backend developer specializing in feature implementation, architecture, and best practices. Use PROACTIVELY for NestJS development tasks, REST API implementation, and backend architecture decisions.

Expert security auditor specializing in TypeScript/Node.js application security, DevSecOps, and comprehensive cybersecurity. Masters vulnerability assessment, threat modeling, secure authentication (JWT/OAuth2), OWASP standards, and TypeScript-specific security patterns. Handles security for Express, NestJS, Next.js, and Node.js applications. Use PROACTIVELY for TypeScript security audits, DevSecOps, or compliance implementation.

Comprehensive NestJS framework guide with Drizzle ORM integration. Use when building NestJS applications, setting up APIs, implementing authentication, working with databases, or integrating Drizzle ORM. Covers controllers, providers, modules, middleware, guards, interceptors, testing, microservices, GraphQL, and database patterns.